Cell Therapy Primer
*This microcourse includes optional CPE Credits and is powered by Biotech Primer, a trusted leader in life science training that simplifies complex topics for non-scientists.
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Optional CPE Credit: 1.0
Overview:
Cell Therapy Primer offers a comprehensive introduction to cell therapy development, manufacturing, and commercialization. This class delves into the scientific benefits and challenges of autologous and allogeneic cell therapies. Cell Therapy Primer focuses especially on Chimeric Antigen Receptors (CARs), their proven approach to treating blood cancer, and their potential applications in solid tumors and beyond. The course also introduces stem cell therapies and applications in regenerative medicine.
- Section 1: Introduction to Cell Therapy: Provides an overview of the first cell therapies and compares two types of cells commercially available today for cell therapy development.
- Section 2: Chimeric Antigen Receptor (CAR): Learn the immune system’s role and how cancer evades it. We end the section by explaining how Chimeric Antigen Receptors (CARs) are used in cell therapy to detect and destroy malignant cells.
- Section 3: Commercial Landscape of CAR-T Cells: CAR-T was first developed by Israeli immunologists Zelig Eshhar and Gideon Gross between 1989-1993. In section three, we discuss the commercial landscape of CAR-T.
- Session 4: Next-Generation Therapies: Explore the next-generation derivatives of CAR-T cells and investigate exciting new cell line frontiers.
By the end of the course, participants will be able to:
- Identify stem cell therapies and list their applications in regenerative medicine.
- Explain the general mechanism of action for Chimeric Antigen Receptors (CARs).
- Evaluate the commercial viability of CAR-T cell therapy to predict its real-world impact to transform medicine.
- Explore ongoing innovations and potential use of CARs with cell types other than T-cells for solid tumors.
- Paraphrase the steps used in manufacturing CAR-T for use in patients.
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