Scientists at the Children's Research Institute at UTSW Discover New Pathways in Kidney Cancer
New research from the Children’s Medical Center Research Institute at UT Southwestern (CRI), published in Nature, reveals that metastatic kidney cancers significantly depend on mitochondrial metabolism, unlike tumors that remain confined to the kidney. In a study involving 80 UT Southwestern patients, Ralph DeBerardinis, M.D., Ph.D., CRI Professor and Howard Hughes Medical Institute (HHMI) Investigator, along with first author Divya Bezwada, Ph.D., and surgeons from the UTSW Department of Urology, investigated how kidney cancers utilize sugars and other nutrients from the blood. Their key finding is that the mitochondrial electron transport chain, a crucial pathway for energy production from nutrients, is much more active in metastatic tumors compared to those that are still localized in the kidney.
Scientists at the Children's Research Institute at UTSW Discover New Pathways in Kidney Cancer