UT Arlington Study Links Estrogen Loss to Increased Heart Disease Risk Through Liver and Immune System Disruption

A University of Texas at Arlington study found that loss of estrogen after menopause may significantly increase cardiovascular risk by disrupting liver function and immune system regulation. Researchers discovered that estrogen helps control inflammation, cholesterol processing, and energy metabolism, and that its decline triggers a systemic inflammatory response linked to heart disease. The study also identified the enzyme IDO1 as a key driver in this process, suggesting a potential non-hormonal therapeutic target for reducing postmenopausal heart disease risk.