UTSW Researchers Develop "self-driving" Microscope

Researchers at UT Southwestern Medical Center have developed a groundbreaking “self-driving” microscope that overcomes two major challenges in microscopy: capturing images of living cells or organisms at vastly different scales and tracking specific structures or regions of interest over extended periods. This innovation, described in Nature Methods, is already enabling observations that were previously impossible with conventional techniques.

For the past two decades, scientists have relied on light-sheet microscopy, a method in which a thin plane of light excites fluorescent probes added to a sample, illuminating specific structures, however, this technique comes with drawbacks.

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